1. University of Kent
  2. Medway School of Pharmacy
    3. Hatem Hassan
Portrait of Dr Hatem Hassan

Dr Hatem Hassan

He/Him

Lecturer in Pharmaceutics and Drug Delivery

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About

Dr. Hatem Hassan obtained his Ph.D. in Pharmaceutical Science from the School of Life Sciences & Medicine at King’s College London in 2016. During his doctoral studies Dr. Hassan investigated the potential of immune-based cancer therapeutic interventions utilising novel cancer vaccine nano-formulations. In addition, Dr. Hassan previously joined the School of Pharmacy at Queen’s University Belfast as a Postdoctoral Research Fellow, in 2018, where his research studies involved the development and assessment of combinatorial immune-based anti-cancer therapies. Before joining the Medway School of Pharmacy as a Lecturer in Pharmaceutics and Drug Delivery, Dr. Hassan held the position of Assistant Professor (Lecturer) at the School of Life and Medical Sciences at University of Hertfordshire (Cairo branch), as well as other academic institutions. In these roles, Dr. Hassan led and collaborated on interdisciplinary research projects exploring drug-loaded nanocarriers, across diverse pathological conditions such as ocular infections, gastrointestinal infections, and joint arthritis. Looking ahead, Dr. Hassan’s objectives over the next five years are to leverage newly developed biocompatible nanocarriers in various collaborative research studies, aiming to bridge the gap between fundamental and translational science to offer more effective therapies.

Research interests

Dr. Hassan's research interests lie at the intersection of materials engineering and biomedical applications, focusing on the development of biocompatible delivery systems for therapeutic agents aimed at addressing challenging medical conditions, such as cancer, degenerative disorders and bacterial infections.

Through an interdisciplinary approach, Dr. Hassan's lab specialises in the formulation, characterisation, and preclinical assessment of novel biodegradable nanocarriers for the delivery of drugs, genes, peptides or vaccines. Additionally, Dr. Hassan's research extends to harnessing immune-modulatory strategies to develop selective and efficient immune-stimulatory or immune-inhibitory therapeutic interventions against complex diseases.

Furthermore, to enhance patient compliance and expand the clinical applicability of nanomedicine, Dr. Hassan's lab also explores the development of nano-sized pharmaceutical formulations tailored for non-invasive administration routes, such as oral, nasal, and transdermal delivery. Through collaborative efforts, Dr. Hassan's lab strives to tackle challenges associated with the clinical translation of innovative therapeutic strategies, aiming to deliver effective solutions to patients in need.

Teaching

The Science of Medicines 1 - MSOP-1014-M01-2024-25
The Science of Medicines 2 - MSOP-1015-M01-2024-25
The Science of Medicines 3 - MSOP-1016-M01-2024-25

Publications

  1. H.A.F.M. Hassan, N.K. Sedky, M.S. Nafie, N.K. Mahdy, I.M. Fawzy, T.W. Fayed, E. Preis, U. Bakowsky, S.A. Fahmy, Sustainable Nanomedicine: Enhancement of Asplatin’s Cytotoxicity In Vitro and In Vivo Using Green-Synthesized Zinc Oxide Nanoparticles Formed via Microwave-Assisted and Gambogic Acid-Mediated Processes, Molecules, 29 (2024) 5327. DOI: doi.org/10.3390/molecules29225327
  2. H.A.F.M. Hassan, M. Haider, S.A. Fahmy, From antigen uptake to immune modulation: the multifaceted potential of peptide nanofibers as vaccine nanocarriers, Materials Advances 5(10) (2024) 4112-4130. DOI: doi.org/10.1039/D4MA00075G
  3. M. Haider, J. Jagal, M. Ali Alghamdi, Y. Haider, H.A.F.M. Hassan, M.B. Najm, M.N. Jayakuma, H. Ezzat, K. Greish, Erlotinib and curcumin-loaded nanoparticles embedded in thermosensitive chitosan hydrogels for enhanced treatment of head and neck cancer, International Journal of Pharmaceutics, (2024) 124825. DOI: doi.org/10.1016/j.ijpharm.2024.124825
  4. M.S. Nafie, N.K. Sedky, H.A.F.M. Hassan, I.M. Fawzy, M.M.M. Abdelhady, U. Bakowsky, S.A. Fahmy, PEG-PLGA core–shell nanoparticles for the controlled delivery of picoplatin–hydroxypropyl β-cyclodextrin inclusion complex in triple-negative breast cancer: In vitro and in vivo study, Nanotechnology Reviews, 13 (2024). DOI: doi.org/10.1515/ntrev-2024-0115
  5. S.A. Fahmy, N.K. Sedky, H.A.F.M. Hassan, N.M. Abdel-Kader, N.K. Mahdy, M.U. Amin, E. Preis, U. Bakowsky, Synergistic Enhancement of Carboplatin Efficacy through pH-Sensitive Nanoparticles Formulated Using Naturally Derived Boswellia Extract for Colorectal Cancer Therapy, Pharmaceutics, 16 (2024) 1282. DOI: doi.org/10.3390/pharmaceutics16101282
  6. M. P. Fawzy, H.A.F.M. Hassan, N.K. Sedky, M.S. Nafie, R.A. Youness, S.A. Fahmy, Revolutionizing cancer therapy: nanoformulation of miRNA-34 – enhancing delivery and efficacy for various cancer immunotherapies: a review, Nanoscale Advances, (2024). DOI: doi.org/10.1039/D4NA00488D
  7. S.G. Abonashey, A.G. Fouad, H.A.F.M. Hassan, A.H. El-Banna, M.A. Shalaby, E. Mobarez, S.A. Fahmy, H.A. El-Banna, Preparation and Characterization of Tiamulin-Loaded Niosomes for Oral Bioavailability Enhancement in Mycoplasma-Infected Broilers, Micro, 4 (2024) 734-750. DOI: doi.org/10.3390/micro4040045
  8. N. K. Sedky, N.K. Mahdy, N.M. Abdel-kader, M.M.M. Abdelhady, M. Maged, A.L. Allam, M.Y. Alfaifi, S.N. Shamma, H.A.F.M. Hassan, S.A. Fahmy, Facile sonochemically-assisted bioengineering of titanium dioxide nanoparticles and deciphering their potential in treating breast and lung cancers: biological, molecular, and computational-based investigations, RSC Advances 14(12) (2024) 8583-8601. DOI: doi.org/10.1039/D3RA08908H
  9. S. G. Abonashey, H.A.F.M. Hassan, M.A. Shalaby, A.G. Fouad, E. Mobarez, H.A. El-Banna, Formulation, pharmacokinetics, and antibacterial activity of florfenicol-loaded niosome, Drug Delivery and Translational Research, (2023). DOI: doi.org/10.1007/s13346-023-01459-9
  10. A. R. Al Jayoush, H.A.F.M. Hassan, H. Asiri, M. Jafar, R. Saeed, R. Harati, M. Haider, Niosomes for nose-to-brain delivery: A non-invasive versatile carrier system for drug delivery in neurodegenerative diseases, Journal of Drug Delivery Science and Technology, 89 (2023) 105007. DOI: doi.org/10.1016/j.jddst.2023.105007
  11. A.-H. AbuBakr, H.A.F.M. Hassan, A. Abdalla, O.M. Khowessah, G.A. Abdelbary, Therapeutic potential of cationic bilosomes in the treatment of carrageenan-induced rat arthritis via fluticasone propionate gel, International Journal of Pharmaceutics, 635 (2023) 122776. DOI: doi.org/10.1016/j.ijpharm.2023.122776
  12. H.A.F.M. Hassan, A.I. Ali, E.M. ElDesawy, A.H. ElShafeey, Pharmacokinetic and pharmacodynamic evaluation of gemifloxacin chitosan nanoparticles as an antibacterial ocular dosage form, Journal of Pharmaceutical Sciences, 111 (2022) 1497-1508. DOI: doi.org/10.1016/j.xphs.2021.12.016
  13. G. Ma, N. Kostevšek, I. Monaco, A. Ruiz, B. Markelc, C.C.L. Cheung, S. Hudoklin, M.E. Kreft, H.A.F.M. Hassan, M. Barker, J. Conyard, C. Hall, S. Meech, A.G. Mayes, I. Serša, M. Čemažar, K. Marković, J. Ščančar, M.C. Franchini, W.T. Al-Jamal, PD1 blockade potentiates the therapeutic efficacy of photothermally-activated and MRI-guided low temperature-sensitive magnetoliposomes, Journal of Controlled Release, 332 (2021) 419-433. DOI: doi.org/10.1016/j.jconrel.2021.03.002
  14. C. C.L. Cheung, G. Ma, K. Karatasos, J. Seitsonen, J. Ruokolainen, C.R. Koffi, H.A.F.M. Hassan, W.T. Al-Jamal, Liposome-templated indocyanine green J- aggregates for in vivo near-infrared imaging and stable photothermal heating, Nanotheranostics, 4 (2020) 91-106. DOI: doi.org/10.7150/ntno.41737
  15. H.A.F.M. Hassan, S.S. Diebold, L. Smyth, A.A. Walters, G. Lombardi, K.T. Al-Jamal, Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances, Journal of Controlled Release, 297 (2019) 79-90. DOI: doi.org/10.1016/j.jconrel.2019.01.017
  16. H.A.F.M. Hassan, L. Smyth, J.T.W. Wang, P.M. Costa, K. Ratnasothy, S.S. Diebold, G. Lombardi, K.T. Al-Jamal, Dual stimulation of antigen presenting cells using carbon nanotube-based vaccine delivery system for cancer immunotherapy, Biomaterials, 104 (2016) 310-322. DOI: doi.org/10.1016/j.biomaterials.2016.07.005
  17. H.A.F.M. Hassan, L. Smyth, N. Rubio, K. Ratnasothy, J.T.W. Wang, S.S. Bansal, H.D. Summers, S.S. Diebold, G. Lombardi, K.T. Al-Jamal, Carbon nanotubes’ surface chemistry determines their potency as vaccine nanocarriers in vitro and in vivo, Journal of Controlled Release, 225 (2016) 205-216. DOI: doi.org/10.1016/j.jconrel.2016.01.030
  18. H. Kafa, J.T.-W. Wang, N. Rubio, R. Klippstein, P.M. Costa, H.A.F.M. Hassan, J.K. Sosabowski, S.S. Bansal, J.E. Preston, N.J. Abbott, K.T. Al-Jamal, Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood–brain barrier in vitro and in vivo, Journal of Controlled Release, 225 (2016) 217-229. DOI: doi.org/10.1016/j.jconrel.2016.01.031
  19. S. Pereira, J. Lee, N. Rubio, H.A.F.M. Hassan, I.B.M. Suffian, J.T.W. Wang, R. Klippstein, B. Ballesteros, W.T. Al-Jamal, K.T. Al-Jamal, Cationic liposome- multi-walled carbon nanotubes hybrids for dual siPLK1 and doxorubicin delivery in vitro, Pharmaceutical Research, 32 (2015) 3293-3308. DOI: doi.org/10.1007/s11095-015-1707-1
  20. N. Rubio, L.M. Hirvonen, E.Z. Chong, J.T.W. Wang, M. Bourgognon, H. Kafa, H.A.F.M. Hassan, W.T. Al-Jamal, D. McCarthy, C. Hogstrand, F. Festy, K.T. Al-Jamal, Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors, Chemical Communications, 51 (2015) 9366-9369. DOI: doi.org/10.1039/C5CC02675J

Last updated 18th December 2024