Anette Teo Hansen Selnø
Research Topic: Biochemical regulation of the Tim-3-Galectin-9 immunosuppressive pathway Qualifications: 2010 - Academy Profession Degree in Chemical and Biotechnical Science (Laboratory Technician), The Metropolitan University College, Copenhagen, Denmark. 2014 - BSc in Molecular Biomedicin, University of Copenhagen, Denmark 2016 - MSc In Molecular Biomedicin, University of Copenhagen, Denmark Scholarships: 2015 - Educational scholarship, Glostrup Kommune 2016 - Københavns Universitets Scholarships - The Laura Bentzens scholarship a travel grant 2018 - EAACI conference scholarship
Not all cancer patients respond to the different current treatments for cancer or some patients' response and then develop adaptive resistance. Therefore, new treatment options are needed. Tim-3/Galectin-9 is an immune checkpoint pathway that is normally used to suppress the immune cells when an immune response should end to avoid collateral tissue damage (autoimmune attack). However, cancer cells (both solid tumors and hematological cancer cells) are very smart, they use the immune cells' own inhibitory checkpoint to kill or suppress cytotoxic activities of lymphoid cells. Thus, targeting the Tim-3/galectin-9 pathway could potentially lead to a new treatment for a variety of different cancers. On the other end in autoimmune disease, like psoriasis, autoreactive T cells attack healthy skin cells. Here the immune cells are the bad guys, so if the healthy cells could use a similar mechanism, like the cancer cell does, to kill or to impair the immune cell function, then you could potentially cure the autoimmune disease. My research focuses on understanding the biochemical regulation of the Tim-3/Galectin-9 immunosuppressive pathway. If we can understand the regulation we might be able to manipulate with the pathway and find a way to 1) suppress galectin-9 production in cancer so the immune cells can go back to fighting the cancer cells, and 2) increase galectin-9 production in healthy cells, so they can protect themselves cells from autoimmune attack.
Supervisors: Dr Vadim Sumbayev and Dr Yuri Ushkaryov Research Group: Biological Sciences
Publications: 1. Hansen Selnø A.T., Sumbayev V.V., Raap U., Gibbs B.F. (2018) Role of Histamine in Inflammatory Diseases. In: Riccardi C., Levi-Schaffer F., Tiligada E. (eds) Immunopharmacology and Inflammation. Springer, Cham. ISBN: 978-3-319-77657-6. 2. Yasinska Inna M., Sakhnevych Svetlana S., Pavlova Ludmila, Teo Hansen Selnø Anette, Teuscher Abeleira Ana Maria, Benlaouer Ouafa, Gonçalves Silva Isabel, Mosimann Marianne, Varani Luca, Bardelli Marco, Hussain Rohanah, Siligardi Giuliano, Cholewa Dietmar, Berger Steffen M., Gibbs Bernhard F., Ushkaryov Yuri A., Fasler-Kan Elizaveta, Klenova Elena, Sumbayev Vadim V. (2019) "The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer ", Frontiers in Immunology. Conference activities: 1. Anette Teo Hansen Selnø, Lars K. Poulsen and Bettina M. Jensen (2017) "The transcription factor E4BP4 is expressed by human basophils and modulated by IL-3". EMBRN 2017 in Prague, Czech Republic. 2. Selnø A. T. H., Gibbs B. F., Raap U., Sumbayev V. V (2018) "Involvement of the Tim-3/Galectin-9 autocrine pathway in autoimmune and allergic reactions". EAACI 2018 in Munich, Germany